|Nano Letters : Drug Intervention and Imaging Diagnosis of Acute Ischemic Stroke|
|Submission:张灿课题组 Date:2019-07-25 Page View:11|
Our latest research on drug delivery and efficacy evaluation of acute ischemic stroke based on cell carriers platform was published in Nano Letters (IF12.279). Ph.D.student Chunming Tang was the first author. Professor Can Zhang and Associate Professor Caoyun Ju were co-corresponding authors.
Neutrophils can infiltrate the ischemic areas of the brain after acute ischemic stroke and release reactive oxygen species, which is also considered to be the main cause of reperfusion injury. Reducing the infiltration of neutrophils after acute ischemic stroke may be an effective treatment. Inspired by the interaction of platelets and neutrophils, the researchers constructed platelet membrane-coated nanoparticles which co-loaded piceatannol and superparamagnetic iron oxide (SPIO), a T2 contrast agent. The nanoparticles can be recognized by neutrophils and the loaded piceatannol can detach the adherent neutrophils at inflammatory sites, thereby reducing neutrophils infiltration and the infarct size. The internalized SPIO can be used for magnetic resonance imaging to monitor neutrophils in real time, which can be used to judge the therapeutic effect and realize the functions integration of drug delivery, imaging diagnosis and therapeutic evaluation. This research provides a new method for the clinical treatment of acute ischemic stroke and neutrophils-associated inflammatory diseases.